Rat renal cell atlas and perturbation by losartan characterized with single-cell and spatial transcriptome information

Naoki Onoda^1,2, Ayako Kawabata², Kumi Hasegawa³, Megumi Sakakura², Itaru Urakawa², Masahide Seki¹, Junko Zenkoh¹, Ayako Suzuki¹ and Yutaka Suzuki¹. Spatial and single-cell transcriptome analysis reveals changes in gene expression in response to drug perturbation in rat kidney. DNA Research. 2022 Mar23;29(2).

¹Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa-shi, Chiba 277-0882, Japan ²Research Core Function Laboratories, Research Unit, R&D Division, Kyowa Kirin Co., Ltd., Machida-shi, Tokyo 194-8533, Japan ³Biomedical Science Research Laboratories 1, Research Unit, R&D Division, Kyowa Kirin Co., Ltd., Machida-shi, Tokyo 194-8533, Japan

---

Original dataset accession: DRA012650

Processed dataset:

You can download the dataset from the link below:

• Download Visium, scRNA-seq dataset
• Size: 7,045,334,484 bytes
• MD5: b8f94f547d26d1e97d789f1e09368ebc

Tissue section images:

Losartan 1

Losartan 2

Losartan 3

Control 1

Control 2

Control 3

---