Reference:
Molecular implications of the stepwise progression of lung adenocarcinoma

  In this study, we performed whole-genome sequencing and multi-layered analysis of early and advanced lung adenocarcinoma. We especially focused on multi-omics features in very early adenocarcinoma cases which are classified by Noguchi classification to understand key molecular events during cancer progression in very early stages. We analyzed a total of 76 non-small cell lung cancer cases including 48 very early adenocarcinomas.
  Newly obtained sequencing data and the related information were deposited in the Japanese Genotype-Phenotype Archive (JGA, http://trace.ddbj.nig.ac.jp/jga), which is hosted by the National Bioscience Database Center (NBDC) and DDBJ with the identifier JGAS000570. Additionally, short read whole-genome sequencing (WGS) and long read WGS datasets from the 20 advanced NSCLC cases that were previously obtained and reported (Sakamoto Y et al. 2020 Genome Res; Sakamoto Y, Miyake S, Oka M et al. 2022 Nat Commun) were deposited in the DDBJ JGA with accession numbers JGAS000065 (JGAD000252 and JGAD000253) and JGAS000349.
 The processed data including DNA methylation profiles, gene expression matrices and spatial omics datasets are available in this page.