The interaction between tumor cells and their microenvironment is believe to be a decisive factor for tumor development. Herein, we characterize spatial RNA profiles obtained from 30 lung adenocarcinoma patients at non-invasive and later invasive stages. We analyzed spatial transcriptome sequencing data in conjunction with higher resolution analysis using in situ RNA profiling. The detailed inspection on each case and the computational modeling based on the observed diverse profiles revealed that the drastic changes in phenotypic appearances of tumor cells are frequently triggered by their interaction with immune cells. The phenomena coincide with the induction of a series of cellular expression programs, which enable transforming tumor cells and their breaking-through against the immune cell barrier, collectively allowing their further progression. The study provides us with actual features how lung tumor develops through interaction within their microenvironments.
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Accession: JGAS000613 * Controlled Access.
Accession: JGAS000677 * Controlled Access.
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| Spatial Omics Analysis Data | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cencer Subtype | Case | FF/FFPE | Section | Visium Spaceranger | Visium Seurat obj | Visium HE file | PhenoCycler | Xenium | Xenium HE file |
| IA | LUAD No.1 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.2 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.2 | FFPE | A | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| IA | LUAD No.2 | FFPE | B | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.2 | FFPE | C | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.2 | FFPE | D | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.3 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.3 | FFPE | A | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| IA | LUAD No.3 | FFPE | B | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.4 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.4 | FFPE | C | Donwload | Donwload | Donwload | Donwload | - | - |
| IA | LUAD No.4 | FFPE | D | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.5 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| IA | LUAD No.14 | FF | - | Donwload | Donwload | Donwload | - | Donwload | Donwload |
| IA | LUAD No.16 | FF | - | Donwload | Donwload | Donwload | - | Donwload | Donwload |
| IA | LUAD No.17 | FF | - | Donwload | Donwload | Donwload | - | Donwload | Donwload |
| AIS Noguchi TypeA | TSU-20 | FF | 1 | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| AIS Noguchi TypeA | TSU-20 | FF | 2 | Donwload | Donwload | Donwload | - | - | - |
| AIS Noguchi TypeA | TSU-23 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| AIS Noguchi TypeA | TSU-25 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | |
| AIS Noguchi TypeB | TSU-19 | FF | a-1 | Donwload | Donwload | Donwload | |||
| AIS Noguchi TypeB | TSU-19 | FF | a-2 | Donwload | Donwload | Donwload | |||
| AIS Noguchi TypeB | TSU-19 | FF | b-1 | Donwload | Donwload | Donwload | |||
| AIS Noguchi TypeB | TSU-19 | FF | b-2 | Donwload | Donwload | Donwload | |||
| AIS Noguchi TypeB | TSU-21 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| AIS Noguchi TypeB | TSU-22 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| AIS Noguchi TypeB | TSU-24 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| AIS Noguchi TypeB | TSU-26 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| AIS Noguchi TypeB | TSU-35 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-27 | FF | 1 | Donwload | Donwload | Donwload | - | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-27 | FF | 2 | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-28 | FF | 1 | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-28 | FF | 2 | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-30 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-31 | FF | - | Donwload | Donwload | Donwload | Donwload | - | - |
| MIA Noguchi TypeC | TSU-32 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-33 | FF | - | Donwload | Donwload | Donwload | Donwload | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-34 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-36 | FF | - | Donwload | Donwload | Donwload | - | Donwload | Donwload |
| MIA Noguchi TypeC | TSU-37 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-38 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-39 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-40 | FF | - | Donwload | Donwload | Donwload | - | - | - |
| MIA Noguchi TypeC | TSU-41 | FF | - | Donwload | Donwload | Donwload | - | Donwload | Donwload |